Background: The study of spondyloarthritis in Peru dates back to 1980. The frequency and occurrence of the illness is unknown, as is the presence of HLA-B27. A prevalence study of rheumatic diseases in Peru that looked for spondyloarthritis showed it to be 0,4%. HLAB27 was found in 33% of the patients. Objectives: To describe the clinical, socio-demographics, radiological and genetic characteristics of the patients with spondyloarthritis who are attended by the department of rheumatology at the Hospital Nacional E. Rebagliati in Lima-Perú. Methods: Descriptive analysis and transferring of the information gathered from Peruvian patients with spondyloarthritis between January 2007 and December 2008 stored in the electronic web page of REGISPONSER. SPSS version 13.0 was used for statistical analysis. Results: We included 60 patients (39 men [65%]) averaging 40 years of age. The diagnosis established with a higher frequency was ankylosing spondylitis and, in second place juvenile spondyloarthritis. Thirty one percent was related to HLA-B27 and 18.6% had a familiar history of spondyloarthritis. The lower extremities were affected with a higher frequency and inflammatory_back pain and sacroiliac syndrome were the most frequent axial manifestation. We encountered tarsitis in 31 patients (53.4%). The most utilized treatment was sulfasalazine. Conclusion: The clinical, demographics and radiological characteristics of Peruvian patients with spondyloarthritis are similar to those from other Latin-American countries. Ankylosing spondylitis is diagnosed most frequently in men and 31% are HLA-B27 positive.