We describe two new species of Ranitomeya (family Dendrobatidae), R. yavaricola sp. nov. and R. cyanovittata sp. nov., from Peru. Ranitomeya yavaricola sp. nov. is morphologically similar to certain other species of Ranitomeya (in particular R. flavovittata), but the new species can be easily distinguished from all other species of Ranitomeya based on its unique limb coloration: solid bronze without black markings. Despite having searched in numerous localities throughout this region, we have found the new species at only a single locality near the confluence of the Yavarí and Yavari-Mirin rivers. Based on acoustic and molecular data, the new species is a member of the vanzolinii group, and is sister to the second new species, R. cyanovittata. Ranitomeya cyanovittata sp. nov. is only known from a single locality in the Sierra del Divisor in Amazonian Peru. This species can be easily distinguished from the other species of Ranitomeya by a unique coloration pattern that consists of just two colors: black background with blue lines or reticulations. Copyright © 2010 Magnolia Press.