Child and adolescent measures of the quality of life or subjective well-being are scarce in Latin American countries. Chile is no exception to this situation that represents a gap in the literature for South American countries research. Thus, the aim was to analyze the psychometric properties of the Personal Well-being Index for School Children (PWI-SC) of Cummins et al. Social Indicators Research, 64(2), 159–190, (2003) in a sample of Chilean school children. We use a sample of 1096 pupils between 10 and 12 years old (M = 11.03; SD = 0.89) and residents of three major Chilean cities. Results of Exploratory and Confirmatory Factor Analysis provided evidence for only one single factor solution. Moreover, an acceptable level of internal reliability was observed (α = 0.77). The discussion of results considers other internationals applications of PWI-SC.