The UCV is a major player within the Sistema Nacional de Ciencia, Tecnología e Innovación (National System of Science, Technology and Innovation) in Venezuela. This paper aims to establish the historical weight that this institution represents regarding its production of scientific publications as registered in the Web of Science (WoS), relative to the whole country. The WoS was queried by using the term "Venezuela" as "Country of Origin for the Publication" in order to generate a database, which in turn was used as the source for the current study and for a time frame ranging from 1981 to 2007. Entries corresponding to Health and Quality of Life were segmented based on the UNESCO taxonomy using a functionality offered by the software BIBLIOS. These findings show the importance that research developed by the UCV in these fields of knowledge has for Venezuelan society.