In order to determine trends in accidents and illnesses reported to the Ministry of Labor of Peru, a descriptive study of secondary data from the reports of monthly newsletters from September 2010 to December 2014 was performed. At the national level, 54,596 non-fatal accidents were reported. The rates of non-fatal accidents increased in 2011-2013 (296.5 in 2011, 955.9 in 2012 and 1176.3 in 2013), decreasing in 2014 (878.9). There were 674 fatal accidents whose rates increased between 2011 and 2012 and were reduced between 2013 and 2014. 346 occupational diseases were reported; the most frequent were cases of hearing loss (77), illness by inadequate postures (57) and allergic dermatitis (44). Reports declined from 6.9 in 2011 to 2.3 in 2014. Reports of occupational diseases were declining, which could indicate significant underreporting.