Title
Comparative analysis of the survival of patients with tuberculous meningitis and pulmonary tuberculosis
Other title
Análisis comparativo de la sobrevida de los pacientes con meningitis tuberculosa y tuberculosis pulmonar
Date Issued
01 January 2021
Access level
metadata only access
Resource Type
journal article
Author(s)
CASTRO, JOHANA
SUÁREZ, MARCO
ACUÑA, FÉLIX
Publisher(s)
Ediciones Doyma, S.L.
Elsevier
Abstract
Introduction: Tuberculous meningitis is the most serious manifestation of the disease by Micobacterium tuberculosis with a high rate of mortality and sequela among survivors. Nonspecific clinical features and limited laboratory tests lead to delay in diagnosis and treatment, thus reducing the survival of patients. Objective: Analyze the survival of patients with tuberculous meningitis (TBM) and compare with other pulmonary tuberculosis at Daniel Alcides Carrión Hospital in Huancayo, Perú. Materials and methods: An observational, analytical, retrospective study of patients with the diagnosis of tuberculosis over 14 years old was carried out at Daniel Alcides Carrión Hospital in Huancayo, from January 2015 to December 2019. Results: Of 1168 patients diagnosed with tuberculosis; 4.7% had tuberculous meningoencephalitis; the average age was 33 years old, 69% were men; the characteristics of the cerebrospinal fluid were mononuclear predominance of pleocytosis, associated with hyper proteinorachie, hypoglycorrhachia, and adenosine deaminase values above 9 U/L. The mortality of TBM was 43%; a prolonged time of illness before going to the hospital (p = .03) and a low Glasgow coma scale score (p = .02) were associated with higher mortality. La survival probability of patients with TBM at 20 days after starting treatment was 23% (p:.01; HR: 4.23; 95% CI: 1.44–12.36) and in patients with pulmonary tuberculosis the probability of survival was 79%. Conclusions: TBM shows poorer survival, so it is essential to improve the capacity for early diagnosis and differentiated treatment.
Language
English
OCDE Knowledge area
Neurología clínica
Subjects
Scopus EID
2-s2.0-85119905460
Source
Neurologia Argentina
ISSN of the container
1853-0028
Sources of information:
Directorio de Producción Científica
Scopus