Title
Inferring gene coexpression networks with biclustering based on scatter search
Date Issued
01 December 2011
Access level
open access
Resource Type
conference paper
Author(s)
Universidad Pablo de Olavide Sevilla
Abstract
The identification of regulatory modules is one of the most important tasks in order to discover disease markers. This paper presents a methodology to infer coexpression networks based on local patterns in gene expression data matrix. In the proposed algorithm two steps can clearly be differentiated. Firstly, a Biclustering procedure that uses a Scatter Search schema to find biclusters and, secondly, a network extraction procedure based on linear correlations among the genes of the previously obtained bicluster. Experimental results from Yeast cell Cycle are reported where three different algorithms have been applied. Also, a possible understanding of one of the obtained networks has been presented from a biological point of view. © 2011 IEEE.
Start page
1091
End page
1096
Language
English
OCDE Knowledge area
Otros temas de BiologÃa
Genética, Herencia
Subjects
Scopus EID
2-s2.0-84857542906
ISBN
9781457716751
Source
International Conference on Intelligent Systems Design and Applications, ISDA
Resource of which it is part
International Conference on Intelligent Systems Design and Applications, ISDA
ISSN of the container
21647143
ISBN of the container
978-145771675-1
Conference
11th International Conference on Intelligent Systems Design and Applications, ISDA'1122 November 2011through 24 November 2011
Sponsor(s)
Machine Intelligence Research Labs (MIR Labs)University of CordobaMinistry of Science and Innovation of Spain
Sources of information:
Directorio de Producción CientÃfica
Scopus