The aim of this retrospective study was to determine the frequency of tumors in the reproductive organs of female canines and felines, based on histopathological records of the Animal Pathology Laboratory of the National University of San Marcos (period 2007-2015), and to correlate breed, age and anatomical site with the histopathological diagnosis. The frequency of neoplasia in the canine reproductive organs was 5.99 ± 1.16% IC95% and in feline was 4.41 ± 4.88%. In bitches, tumors were most often found in pure breeds (60.22 ± 9.95%), between 8 to 12 years (43.75 ± 9.92%) and mostly in the vulvar area (37.50 ± 9.68). The most common tumor in the ovary was the tumor of granulosa cells (47.6 ± 21.4%), while in uterus was leiomyoma (50.0 ± 40.0%) and in the vulva and vagina was the transmissible venereal tumor (39.4 ± 16.7%). In cats two dysgerminomas in ovaries and one polypoid fibro-adenoma in uterus was found.