Irritable Small Bowel (ISB) is the most common disorder in the gastroenterological practice. On the other hand, depression, is also common, and can produce somatic symptoms that could mislead the physician with respect to bowel diseases, particularly of the digestive system. The main objective of this work was to determine the relationship between lower digestive tract symptoms and symptoms of depression in a population of high socio-economic status in five districts of Lima. A cross-sectional study on the prevalence of lower digestive tract symptoms and symptoms of depression was carried out, together with a case-control study to evaluate the relationship between lower digestive tract symptoms and symptoms of depression. It included 300 individuals. The Beck Inventory for Depression and the Manning Criteria for ISB were used. Significant association (p<0.05) between lower digestive tract symptoms and symptoms of mild depression was found, with a OR=10.9 and significant statistical association between symptoms of moderate depression and lower digestive tract symptoms (p=0.01 and OR=3.48). It is concluded that there is a connection between lower digestive tract symptoms and symptoms of depression, in a population of high socio-economic status in five districts of Lima.