Title
Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues
Date Issued
01 April 2019
Access level
metadata only access
Resource Type
journal article
Author(s)
Abstract
Objectives: The aim of this study was to analyze the immunohistochemical expression of fatty acid synthase (FASN) and cyclooxygenase-2 (COX-2) in tooth germ (TG), ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic fibroma (AF), and ameloblastic fibrosarcoma (AFS). Study Design: Immunohistochemistry for FASN and COX-2 was performed in 10 TG, 44 AM, 10 AC, 9 AF, and 5 AFS specimens. The results were analyzed by using the immunoreactive score (IRS) and Kruskal-Wallis test followed by Dunn's post-test. Results: Most TG specimens were strongly positive for FASN, whereas COX-2 was weak or negative. All AM and AC specimens expressed both proteins. In AF specimens, FASN and COX-2 were variably expressed in the epithelium and negative in the mesenchyme. In AFS specimens, FASN was strongly positive in the malignant mesenchyme and variable in the epithelium; COX-2 was focal or weak in both components. FASN expression showed significant differences in the following comparisons: TG vs AC, AM vs AC, and AF vs AFS. Differences in COX-2 were significant when comparing TG specimens with AM, AC, and AF specimens. Conclusions: The results suggest that FASN and COX-2 overexpression may have a role in the pathogenesis of AM and AC, whereas in AFS, FASN seems to be mainly involved. Further studies are necessary to clarify these mechanisms and their clinical implications.
Start page
309
End page
317
Volume
127
Issue
4
OCDE Knowledge area
Patología
Odontología, Cirugía oral, Medicina oral
Scopus EID
2-s2.0-85060550493
PubMed ID
Source
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
ISSN of the container
22124403
Sponsor(s)
We greatly appreciate the support of Dr. Florence Cuadra Zelaya (Oral Pathology Section, Piracicaba Dental School, University of Campinas, Sao Paulo, Brazil) for assistance with statistical methodology.
All reviews in this study of human participants were performed in accordance with the ethical standards of the institutional and/or national research committee and by following the tenets of the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Because this was a retrospective review, informed consent was not required. This study was approved by the Ethical Committee of the School of Dentistry, Universidad de la Republica (register number 091900-000113-14).
This work was supported in part by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, Brazil (CAPES; Finance Code 001). This work was supported in part by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, Brazil (CAPES; Finance Code 001). We greatly appreciate the support of Dr. Florence Cuadra Zelaya (Oral Pathology Section, Piracicaba Dental School, University of Campinas, Sao Paulo, Brazil) for assistance with statistical methodology. This work was supported in part by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, Brazil (CAPES; Finance Code 001).
Sources of information:
Directorio de Producción Científica
Scopus