The Lurin river is located in the coastal part of Peru. Although, in general the climate is arid, in some month of the year in possible to have some precipitation. This situation is the main cause of deficits in water resources management, inefficient growth of agriculture and livestock, lack of climatic and hydrometric information in the Basin. The TETIS Model which is a spatially distributed hydrological has been applied to modeling the Lurín river basin, for which information on precipitation, evapotranspiration and flow, geomorphological maps (MED, accumulated cells, flow direction, slope, speed), maps of hydrological parameters of static storage (Hu) and hydraulic conductivity of the soil (Ks) and the map of hydraulic conductivity of the aquifer (Kp), the map of vegetation cover and the information referred to the index of vegetation (λ) by type of cover. In the hydrometric station of Antapucro and San Damian, the daily calibration and validation of the model were carried out. Obtaining the Nash indices (NSE), normalized mean square error (RSR) and volume error (Ev) of (0.7551, 0.4949, 0.701%) for calibration and (0.7611, 0.4888, –14.629%) for validation, respectively; the parameters with the highest sensitivity in the model being the evapotranspiration correction factor (FC2) and the rain interpolation factor (β). The daily flows were simulated from 1969 to 2019, the annual water balance an offer of 121.36 hm3 and demand of 111.59 hm3 were obtained, which corresponds mainly to agricultural use. In the water balance there is a surplus from January to May of 58.44 hm3, which is discharged to the sea due to the inexistent reservoir infrastructure in the basin. In the others months, June to December, there is a deficit of 48.67 hm3 due to the lack of rain.