Title
Application of a cost-effectiveness analysis of pathogen-specific vaccines against gastroenteritis to a military population in a developing country setting
Date Issued
28 February 2020
Access level
open access
Resource Type
journal article
Author(s)
Tallant A.
Guerra R.G.
Quigley D.
Stiegmann R.
Mirelman A.J.
Riddle M.S.
Johns Hopkins Bloomberg School of Public Health
Johns Hopkins Bloomberg School of Public Health
Publisher(s)
Elsevier Ltd
Abstract
Vaccine implementation planning in low- and middle-income countries (LMIC) often focuses on children without considering special adult populations. We adapted an economic model developed by the United States Department of Defense (DoD) to evaluate the cost-effectiveness of vaccine acquisition strategies for Campylobacter-, ETEC-, Shigella-, and norovirus-associated gastroenteritis. We compared implementation costs with current medical management in the Peruvian armed forces, a special population of low- and middle-income (LMIC) adults with a high incidence of infectious gastroenteritis. Pathogen-specific vaccine implementation resulted in calculated cost-effectiveness ratio (CER) per duty day lost averted (CERDDL) of $13,741; $1,272; $301; and $803, and a CER per diarrhea day averted of $2,130; $215; $51; and $199 for Campylobacter, ETEC, Shigella, and norovirus, respectively. These estimates compare favorably to CERDDL estimates from high-income military population and suggest that implementing vaccines gastroenteritis may be cost-effective in the Peruvian military population.
Start page
2292
End page
2297
Volume
38
Issue
10
Language
English
OCDE Knowledge area
EstadÃsticas, Probabilidad
Medicina clÃnica
Subjects
Scopus EID
2-s2.0-85078832554
PubMed ID
Source
Vaccine
ISSN of the container
0264410X
Source funding
U.S. Department of Defense
Sponsor(s)
This work was supported by the National Institutes of Health Fogarty International Center through the Fogarty Global Health Fellows UJMT Consortium [grant number 1R25 TW009340-01 ]; the US Fulbright Program; the Pat Tillman Foundation; the Thrasher Research Fund Early Career Award; the Johns Hopkins Bloomberg School of Public Health Procter & Gamble Fellowship; the R. Bradley Sack Family Award; the National Institute of Allergy and Infections Diseases [grant number R21 AI099737 ]; and the US Department of Defense Global Emerging Infections Surveillance and Response System [work number 847705 82000 25 GB B0016 ].
The authors thank the Peruvian military, particularly personnel at the Vargas Guerra Army base in Iquitos, Peru, for their continued support and collaboration. This work was supported by the National Institutes of Health Fogarty International Center through the Fogarty Global Health Fellows UJMT Consortium [grant number 1R25 TW009340-01]; the US Fulbright Program; the Pat Tillman Foundation; the Thrasher Research Fund Early Career Award; the Johns Hopkins Bloomberg School of Public Health Procter & Gamble Fellowship; the R. Bradley Sack Family Award; the National Institute of Allergy and Infections Diseases [grant number R21 AI099737]; and the US Department of Defense Global Emerging Infections Surveillance and Response System [work number 847705 82000 25GB B0016].
Sources of information:
Directorio de Producción CientÃfica
Scopus