Quinoxaline derivatives are compounds that show a great spectrum of biological activities and offer a great variety of possibilities for its structural modification. We can detail quinoxaline 1,4-di-oxides as new anticancer compounds against hypoxic cells. Now, we report the synthesis of new derivatives, 3-[4-(4-nitrofenil)piperazin-1-il]-2-quinoxalinecarbonitriles. These compounds are cellular growing inhibitors especially over leucemia celular panel.