Title
Author reply: the master-question: meta-analyses and stopped-early randomized trials-a problem?
Date Issued
01 January 2008
Access level
metadata only access
Resource Type
letter
Author(s)
Bassler D.
Ferreira-Gonzalez I.
Briel M.
Cook D.J.
Devereaux P.J.
Heels-Ansdell D.
Kirpalani H.
Meade M.O.
Rozenberg A.
Schünemann H.J.
H. Guyatt G.
Mayo Clinic
Publisher(s)
Elsevier
Start page
96
End page
98
Volume
61
Issue
1
Language
English
OCDE Knowledge area
Tecnología médica de laboratorio (análisis de muestras, tecnologías para el diagnóstico)
Scopus EID
2-s2.0-36849041643
Source
Journal of Clinical Epidemiology
ISSN of the container
0895-4356
Sponsor(s)
We thank Dr. Goodman for joining the debate on RCTs stopped early for benefit, which helps to raise awareness about this important issue. Dr. Goodman's skepticism about our conclusion highlights the need for further empirical research. We have launched the Study of Policy of Interim Truncation—2 (STOPIT-2), an international methodological study funded by the British Medical Research Council [10] . STOPIT-2 seeks to determine the magnitude and determinants of bias that early stopping introduces by comparing treatment effects of studies stopped early for benefit with a pooled estimate of RCTs addressing the same question as the stopped-early studies [10] . Hopefully, the results of STOPIT-2 will, in the future, guide the interpretation of stopped-early trials, and will inform clinicians, investigators, institutional review boards, funding agencies, and DMCs about the appropriate use of stopping rules in clinical trials.
Sources of information:
Directorio de Producción Científica
Scopus