Title
Vascular calcifications and their poor association with metabolic bone disease in a hemodialysis population
Other title
Calcificaciones vasculares y su pobre asociación con el trastorno bioquímico óseo en una población en hemodiálisis
Date Issued
01 January 2020
Access level
metadata only access
Resource Type
journal article
Author(s)
Abstract
Introduction: Vascular calcifications are part of the mineral bone disorder in chronic kidney disease and they are one of the main causes of mortality. There is plausibility and experimental association between metabolic disorder and vascular calcification; however, there is no enough evidence for their clinical connection. Objective: To determine the association of biochemical alterations of mineral bone disorder (calcium: >10 mg/dL; phosphorus: >5 mg/dL; paratohormone: >300 pg/mL) with vascular calcifications evaluated according to the Kauppila score. Methods: An observational, cross-sectional, analytical study was performed. 97 stage V CKD patients undergoing hemodialysis were included; 69% were prevalent cases (diagnosed within >6 months) with an average time of 5.3 years. A statistical association was established according to Pearson‘s Chi2 test and logistic regression. Results: A level of vascular calcification was found with a Kauppila score of >1 in 60.8% of patients and of ≥3 in 43.3% of them, being predominant in the prevalent dialysis population (78.6%). However, no statistical association was found with mineral bone disorder in the chi-squared bivariate analysis or the logistic regression. Conclusions: A crosssectional test of the biochemical alteration in mineral bone disorder does not allow to find an association with vascular calcifications. It is necessary to establish a prospective calciumphosphorus positive balance first to prove this association.
Start page
25
End page
31
Volume
40
Issue
1
Language
Spanish
OCDE Knowledge area
Medicina clínica
Subjects
Scopus EID
2-s2.0-85083699172
Source
Revista de Nefrologia, Dialisis y Trasplante
ISSN of the container
03263428
Sources of information:
Directorio de Producción Científica
Scopus