Title
A “Janus” face of the RASSF4 signal in cell fate
Date Issued
01 January 2022
Access level
metadata only access
Resource Type
review
Author(s)
Liu A.
Zhou K.
Martínez M.A.
Martínez M.
Martínez-Larrañaga M.R.
Wang X.
Anadón A.
Ares I.
Universidad Complutense de Madrid(UCM)
Publisher(s)
John Wiley and Sons Inc
Abstract
RASSF4 (Ras-association domain family 4) is a protein-coding gene, regarded as a tumor suppressor regulated by DNA methylation. However, RASSF4 acts as a “Janus” in cell fate: death and survival. This review article focuses on the regulatory mechanisms of RASSF4 on cell death and cell survival and puts forward a comprehensive analysis of the relevant signaling pathways. The participation of RASSF4 in the regulation of intracellular store-operated Ca2+ entry also affects cell survival. Moreover, the mechanism of inducing abnormal expression of RASSF4 was summarized. We highlight recent advances in our knowledge of RASSF4 function in the development of cancer and other clinical diseases, which may provide insight into the controversial functions of RASSF4 and its potential application in disease therapy.
Start page
466
End page
479
Volume
237
Issue
1
Language
English
OCDE Knowledge area
Biología celular, Microbiología
Bioquímica, Biología molecular
Scopus EID
2-s2.0-85115318019
PubMed ID
Source
Journal of Cellular Physiology
ISSN of the container
00219541
Sponsor(s)
We apologize to any contributors to this field of research whose work is not cited here owing to space restrictions. This study was supported by National Key R & D Program of China (2018YFC1603005) and by the Fundamental Research Funds for the Central Universities (2662020DKPY020) and Project Ref. PID 2020‐115979RR‐C33 from the Ministerio de Ciencia e Innovación, Spain.
We apologize to any contributors to this field of research whose work is not cited here owing to space restrictions. This study was supported by National Key R & D Program of China (2018YFC1603005) and by the Fundamental Research Funds for the Central Universities (2662020DKPY020) and Project Ref. PID 2020-115979RR-C33 from the Ministerio de Ciencia e Innovaci?n, Spain.
Sources of information:
Directorio de Producción Científica
Scopus