Title
Design of a multifunctionalizable BODIPY platform for the facile elaboration of a large series of gold(i)-based optical theranostics
Date Issued
2018
Access level
metadata only access
Resource Type
journal article
Author(s)
Pliquett J.
Amor S.
Laly M.
Racoeur C.
Rousselin Y.
Denat F.
Bettaïeb A.
Fleurat-Lessard P.
Paul C.
Goze C.
Bodio E.
Univ. Bourgogne Franche-Comté
Publisher(s)
Royal Society of Chemistry
Abstract
A simple trifunctional BODIPY platform was designed. The high potential of this platform was validated via the elaboration of twelve optical theranostics. More specifically, we reported on the synthesis, the characterization, the photophysical properties, and the evaluation of the hydrophilicity properties of the different BODIPY derivatives, as well as a theoretical rationalization of the intriguing chemical behavior of some of them. The antiproliferative evaluation and confocal imaging of the different compounds in three human and murine cancer cell lines were performed and analysed, along with the measurement of gold(i) uptake in one cancer cell line via ICP-MS.
Start page
11203
End page
11218
Volume
47
Issue
32
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular
Scopus EID
2-s2.0-85051717879
PubMed ID
Source
Dalton Transactions
ISSN of the container
14779226
Sponsor(s)
Support was provided by the Conseil Régional de Bourgogne (PhD JCE grant # 2015-9205AAO033S04139/BG0003226), the Conseil Régional de Bourgogne Franche-Comté, the Ministère de l’Enseignement Supérieur et de la Recherche, the Centre National de la Recherche Scientifique (CNRS), and the French Research National Agency (ANR) via the project JCJC “SPID” ANR-16-CE07-0020, the Université de Bourgogne, and the École Pratique des Hautes Études (EPHE). This work is part of the project PHARMACOIMAGERIE ET AGENTS THERANOSTIQUES and of the project CHIMIE DURABLE, ENVIRONNEMENT ET AGROALIMENTAIRE, supported by the Université de Bourgogne, Conseil Régional de Bourgogne through the plan d’actions régional pour l’innovation (PARI) and the European Union through the PO FEDER-FSE Bourgogne 2014/2020 programs. FrenchBIC and GDR CNRS AIM are acknowledged for fruitful discussion. Mr Soustelle and Ms M.-J. Penouilh are gratefully acknowledged for HR-MS, NMR analyses. Plateforme DimaCell, U. Bourgogne Franche-Comté, F21000 Dijon, France. The society Oncodesign® is acknowledged for fruitful discussion and for their support. Mr Jacques Pliquett gratefully acknowledges Ms Lucile Dondaine for her valuable advice on the biological tests. The calculations were performed using HPC resources from DNUM CCUB (Centre de Calcul de l’Université de Bourgogne).
Sources of information:
Directorio de Producción Científica
Scopus