The effect of partial replacement of soybean meal (SM) by hydrolyzed protein of the cellular content of yeast (HPCCY), isolated protein of soy (IPS), hydrolyzed protein of intestinal mucosa membrane of swine (HPIMS) in diets with dried whole milk (DWM) on performance, serum urea and diarrhea incidence of weaned pigs. Fourteen piglets weaned at 21 days old (20 barrows and 20 females), were allotted to a completely randomized experimental block design with five treatments (diets) and 8 replications each. The diets were fed in three phases according to the animal age. In the pre-initial phase 1 (21 to 35 days of age): corn-soy diet, diet with 15% DWM, diet with 15% DWM + 3,5% HPIMS, diet with 15% DWM + 5% IPS, diet with 15% DWM + 5% HPCCY. In the phase pre-initial 2 (36 to 49 days of age) a corn-soy diet was maintained and DWM was reduced to 7.5% in all diets, HPIMS to 1.5%; IPS to 4% and HPCCY was maintained in 5%. In the phase initial (50 a 70 days of age) was maintained the corn-soybean based diet, DWM was removed of all the diets and the animals that received the treatments with DWM and DWM + HPIMS in the phases pre-initial 1 and 2, they were fed corn-soy diet, IPS was reduced to 3% and HPCCY to 2.5%. In the period from 21 to 35 days, the diet DWM + IPS provided the highest daily weight gain and better feed conversion. In the following phases, there was not difference in the performance among diets. Up to five days post weaning, pigs fed SM and DWM + IPS showed the lowest diarrhea incidence. The levels of serum urea were not influenced by the diets. The use of IPS, HPIMI and HPCCY in complex diets containing dried whole milk represents a viable biologically alternatives in diets for pigs. © 2008 Sociedade Brasileira de Zootecnia.