This article reports on results of the administration of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) to 500 high school students (aged 16–19) in the Peruvian Amazon. Results indicate 68.6% of the sample reported consumption of alcohol in the past three months. One out of four students reported high risk involvement with at least one substance while 1 out of 3 reported moderate risk. This is one of the few instances in which ASSIST was administered to adolescents and offers possibilities for further reflection on drug use at early ages.