Critical applications must rely on fault-tolerant systems in order to guarantee an error-free execution since the cost of a system fault can be paid in terms of millions of dollars or, even worse, in terms of human lives. In this context, Dynamic Partial Reconfiguration (DPR) enables a more optimized and reliable usage of stateof- the- art Xilinx SRAM-based Field Programmable Gate Arrays (FPGA) resources over space and time. DPR techniques make use of the Internal Configuration Access Port (ICAP), an internal FPGA interface that allows changing on the fly the functionality of a portion of its logic. Unfortunately, a standard DPR flow requires the use of at least a microprocessor (MicroBlaze, PowerPC or ARM), extra memories due to the microprocessor and several peripherals, which results in dense and complex designs that may be easily corrupted by radiation incidence. This chapter presents a generic DPR manager core that has been optimized to provide high reliability. Results are shown in terms of performance, resources utilization and fault tolerance capability, which reinforce its advantages over traditional solutions.