This research aims to evaluate the effect of fluid extract of flowers of Passiflora peduncularis “puro puro” and guided meditation in patients with generalized anxiety disorder. A randomized parallel group, placebo controlled trial was performed, with 57 participants, divided into three groups, two experimental and one control. Anxiety levels were assessed using the Hamilton Anxiety Scale HAM-A. Phytotherapeutic and guided meditation interventions reduced anxiety levels at different weeks of treatment, finding statistical significance (p<0.05) in these results.