The present study was developed with the objective of determining if Arthrospira jenneri has an antihyperlipidemic effect. Arthrospira jenneri or spirulina, blue-green planktonic algae, is gaining increasing attention due to its nutritional and medicinal properties, since it has essential amino acids and vitamins, because of this it’s used in the production of nutritional supplements. To verify if it has a lipid-lowering effect, were made in vitro studies such as total phenolic compounds and DPPH and in vivo tests using mice model, who took a blood sample after treatment with Arthrospira jenneri at two doses (0.05g/100g and 0.3g/100g), determined total cholesterol, triglycerides, and catalase enzyme activity. The content in phenolic compounds was 9.81 ± 0.197 (EAG / g) and antioxidant capacity of Arthrospira jenneri was determined which was 32.86 ± 3.702 (ET / g). At the dose 0.05g / 100g, it presented a significant decrease in cholesterol levels and a significant decrease in triglyceride levels, and at dose 0.3g / 100g, it generates a significant increase in catalase activity. It`s concluded that Arthrospira jenneri was shown to have a lipid lowering effect.