Title
Trends in the initial management of vestibular schwannoma in the United States
Date Issued
01 October 2019
Access level
metadata only access
Resource Type
journal article
Author(s)
Leon J.
Trifiletti D.
Waddle M.
Vallow L.
Ko S.
May B.
Tzou K.
Lundy L.
Chaichana K.
Vibhute P.
Peterson J.
Mayo Clinic
Publisher(s)
Churchill Livingstone
Abstract
Introduction: Vestibular schwannomas are benign tumors of the 8th cranial nerve. Initial treatment options include active surveillance, surgery, and/or radiation therapy. We analyzed the United States National Cancer Database (NCDB) for patients with vestibular schwannomas and evaluated the initial management trends after diagnosis. Methods: We queried the NCDB for patients with vestibular schwannomas, excluding patients who did not have schwannomas of the vestibulocochlear nerve. Categorical and continuous variables were analyzed, and multivariate Cox regression analyses were performed to investigate for predictors of initial local therapy at diagnosis. All statistical analyses were performed using commercially available software (SPSS, Version 22; SPSS Inc., Chicago, IL). Results: A total of 28,446 patients met the inclusion criteria. In this cohort, 7351 (25.8%) underwent observation, 12,362 (43.5%) underwent surgical resection, 7785 (27.4%) underwent SRS, 824 (2.9%) underwent EBRT, and 124 (0.4%) underwent RT NOS. On multivariate analysis, younger age, increased distance to treating facility, Charlson/Deyo score of 1, primary payer insurance, facility location and facility type (academic or cancer center) (p < 0.001) were all factors that predicted patients undergoing initial definitive treatment. Conclusion: Age, distance to treating facility, Charlson/Deyo score, primary payer, facility location, and facility type are factors that influence initial treatment for patients with vestibular schwannoma. Clinical stratification systems are needed to identify which patients would benefit most from initial local therapy versus active surveillance.
Start page
174
End page
178
Volume
68
Language
English
OCDE Knowledge area
Neurociencias Neurología clínica
Scopus EID
2-s2.0-85068934785
PubMed ID
Source
Journal of Clinical Neuroscience
ISSN of the container
09675868
Sources of information: Directorio de Producción Científica Scopus