Title
Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms
Date Issued
01 January 2001
Access level
open access
Resource Type
journal article
Author(s)
Baylor College of Medicine
Publisher(s)
American Society for Microbiology
Abstract
Jejunal biopsies from volunteers challenged with Cryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β mRNA. Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-α; 14% expressed IL-1β. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-α and IL-1β are not key mediators of diarrhea in human cryptosporidiosis.
Start page
1172
End page
1174
Volume
69
Issue
2
Language
English
OCDE Knowledge area
Gastroenterología, Hepatología
Inmunología
Scopus EID
2-s2.0-0035145771
PubMed ID
Source
Infection and Immunity
ISSN of the container
00199567
Sponsor(s)
National Institute of Allergy and Infectious Diseases P30AI036211 NIAID
Sources of information:
Directorio de Producción Científica
Scopus