Title
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
Date Issued
01 June 2015
Access level
open access
Resource Type
review
Author(s)
Nahta R.
Al-Mulla F.
Al-Temaimi R.
Amedei A.
Andrade-Vieira R.
Bay S.
Brown D.G.
Calaf G.M.
Castellino R.C.
Cohen-Solal K.A.
Colacci A.
Cruickshanks N.
Dent P.
Di Fiore R.
Forte S.
Goldberg G.S.
Hamid R.A.
Krishnan H.
Laird D.W.
Lasfar A.
Marignani P.A.
Memeo L.
Mondello C.
Naus C.C.
Raju J.
Roy D.
Roy R.
Ryan E.P.
Salem H.K.
Ivana Scovassi A.
Singh N.
Vaccari M.
Vento R.
Vondráček J.
Wade M.
Woodrick J.
Bisson W.H.
Universidad de Tarapacá
Publisher(s)
Oxford University Press
Abstract
As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
Start page
S2
End page
S18
Volume
36
Language
English
OCDE Knowledge area
Salud pública, Salud ambiental
Oncología
Scopus EID
2-s2.0-84937697813
PubMed ID
Source
Carcinogenesis
ISSN of the container
01433334
Sponsor(s)
National Cancer Institute - R01CA157754.
Sources of information:
Directorio de Producción Científica
Scopus