Title
Tau monoclonal antibody generation based on humanized yeast models: Impact on tau oligomerization and diagnostics
Date Issued
13 February 2015
Access level
open access
Resource Type
journal article
Author(s)
Rosseels J.
Van Den Brande J.
Violet M.
Jacobs D.
Grognet P.
Huvent I.
Caldara M.
Swinnen E.
Papegaey A.
Caillierez R.
Buée-Scherrer V.
Engelborghs S.
Lippens G.
Colin M.
Buée L.
Galas M.C.
Vanmechelen E.
Winderickx J.
Université Lille Nord de France
Publisher(s)
American Society for Biochemistry and Molecular Biology Inc.
Abstract
Background: Oligomers of protein Tau are associated with neurodegenerative diseases. Results: New antibodies were generated and validated that recognize different degrees of oligomerization of protein Tau. Conclusion: Low order and higher order oligomers differ in C-terminal Tau phosphorylation and reflect consecutive stages in disease progression. Significance: Antibodies recognizing Tau oligomers provide insight into disease etiology and are promising diagnostic tools.
Start page
4059
End page
4074
Volume
290
Issue
7
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular
Scopus EID
2-s2.0-84922823517
PubMed ID
Source
Journal of Biological Chemistry
ISSN of the container
00219258
Sources of information:
Directorio de Producción Científica
Scopus