Most of the studies on entrepreneurial intention have been applied in university students under a face-to-face modality. However, it is also important to consider the context of the students in the virtual mode, that is, those students at a distance, so the objective of this study is to identify the most influential factors in the entrepreneurial intention of enrolled psychology university students in virtual mode. For this, a study with a quantitative approach is applied in which the Factorial Analysis statistical technique is used from the application of a survey to 178 psychology students from the Catholic North University Foundation. The convergent and discriminant validity of the proposed model is evaluated from the Theory of Planned Behavior and the Business Event Model, as well as the reliability and contrast of hypotheses. The results allow identifying relevant relationships between attitude, perceived behavior control, entrepreneurial behavior, and current behavior control with respect to the entrepreneurial intention of the surveyed students. Based on these results, it is possible to identify the most influential factors in the entrepreneurial intention of students, which allow strengthening from higher education institutions and universities the academic programs aimed at fostering the entrepreneurial spirit of psychology students in the virtual modality.