Objective: The suspicion of an underlying medical cause must guide to the clinical and paraclinical approach when faced with a new case of catatonia. For that purpose, a case is presented in which the aetiology has never been reported in the literature. Clinical case: A 58 year-old man, with no significant medical history, presenting with a catatonic syndrome of one week onset. Neuroimages showed a left parietal tumour with intense surrounding oedema, suspicious of tuberculous granuloma. The oedema was resolved with corticosteroid use, which led to the disappearance of the catatonia. Result: Contrary to other reports where the excision of the tumour mass was followed by the resolution of the catatonia, in this case the treatment of the cerebral oedema resolved the catatonia completely. Conclusion: The case presented highlights the need for the early detection of catatonia in order to be managed appropriately, either symptomatic or causal. As far as we know, there are no previous reports in the literature of catatonia secondary to cerebral oedema.