Title
Detecting volumetric changes in fMRI connectivity networks in schizophrenia patients
Date Issued
02 November 2014
Access level
metadata only access
Resource Type
conference paper
Author(s)
Arbabshirani M.R.
Pattichis M.S.
Calhoun V.D.
University of New Mexico
Abstract
There is a growing interest in identifying neuroimaging-based biomarkers for schizophrenia. Previous studies have shown both functional and structural brain abnormalities in schizophrenia patients. One main category of these findings consists of volumetric abnormalities in brain structure in different cortical and subcortical structures in patients' brain. However there has been little work investigating changes in the brain's functional volumes. Nor has there been work studying differences in brain networks as opposed to single regions. In this study, we investigated the volumes of functional networks as potential biomarkers. Independent component analysis was used to decompose fMRI images into maximally independent spatial maps and corresponding time-courses. Volume of functional networks was computed from subject-specific back reconstructed spatial maps. The results show that different nodes of the default-mode network exhibit volumetric abnormalities in schizophrenia patients. Interestingly these networks are larger in patients compared to controls.
Start page
726
End page
729
Language
English
OCDE Knowledge area
Ingeniería médica
Scopus EID
2-s2.0-84929497603
PubMed ID
ISBN
9781424479290
Source
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Resource of which it is part
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Conference
36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Sponsor(s)
National Institute of Biomedical Imaging and Bioengineering
Sources of information: Directorio de Producción Científica Scopus