Title
Neutralization of the hemorrhagic activity of Bothrops and Lachesis snake venoms by a monoclonal antibody against mutalysin-II
Date Issued
01 January 2000
Access level
metadata only access
Resource Type
journal article
Author(s)
Fundação Ezequiel Dias
Publisher(s)
Elsevier Ltd
Abstract
One mAb reactive with mutalysin-II, a hemorrhagic metalloproteinase isolated from Lachesis muta muta venom, was produced in mice immunized with L. m. muta venom. Indirect ELISA was employed to compare the antigenic cross-reactivity among the venoms from Bothrops snakes. The mAb anti-mutalysin-II efficiently neutralized the hemorrhagic effect of both mutalysin-II and L. m. muta crude venom. Furthermore, the mAb were cross-reactive with B. alternatus, B. atrox, B. itapetiningae, B. jararaca and B. neuwiedii and showed variable potencies in neutralizing the hemorrhagic activity of several bothropic venoms. Copyright (C) 1999 Elsevier Science Ltd.
Start page
139
End page
144
Volume
38
Issue
1
Language
English
OCDE Knowledge area
Toxicología
Subjects
Scopus EID
2-s2.0-0344117526
PubMed ID
Source
Toxicon
ISSN of the container
00410101
Sponsor(s)
Funding text
This research was supported by grants from the Brazilian agencies CNPq (Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico) and FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais). CCO and EFS are the recipients of CNPq fellowships.
Sources of information:
Directorio de Producción Científica
Scopus