Title
In situ synthesis and magnetic studies of iron oxide nanoparticles in calcium-alginate matrix for biomedical applications
Date Issued
10 March 2008
Access level
metadata only access
Resource Type
journal article
Author(s)
Morales M.
Finotelli P.
Rocha-Leão M.
Diaz-Aguila C.
Baggio-Saitovitch E.
Rossi A.
Centro Brasileiro de Pesquisas Físicas
Publisher(s)
Elsevier
Abstract
In this work we applied a new route to synthesize magnetic iron oxide nanoparticles into alginate polymer for future application as drug delivery system activated by magnetic external stimuli. Calcium-alginate was used to encapsulate iron oxide nanoparticles, and as scaffold for particle nucleation and its influence on particles size and magnetic properties were studied. The iron oxide mean sizes were between 4.3 and 9.5 nm. Iron is dispersed throughout the polymer matrix mainly as iron oxide particles, and a small fraction as iron (III) occupying calcium sites in the polymer network. The temperature dependence of the Mössbauer spectra is typical of superparamagnetic particles in agreement with the magnetic susceptibility data. © 2007 Elsevier B.V. All rights reserved.
Start page
253
End page
257
Volume
28
Issue
2
Language
English
OCDE Knowledge area
Farmacología, Farmacia
Nano-materiales
Biomateriales
Subjects
Scopus EID
2-s2.0-38349048674
Source
Materials Science and Engineering C
ISSN of the container
09284931
Sponsor(s)
M. A. Morales and P. V. Finotelli thank CNPq and CAPES, respectively, for their fellowships. We also thank CNPq, CAPES, and Millennium Institute for Tissue Bioengineering (IMBT)/CNPq. The alginate was kindly supplied by ISP Alginates Inc.
Sources of information:
Directorio de Producción Científica
Scopus