In 2018 a collaborative project between Politecnico di Milano (PoliMI) and Regione Lombardia (RL) was launched to join forces and expertise toward the improvement of the regional transport infrastructures maintenance management. One of the project goals was the development of regional guidelines aimed to support the design and implementation of monitoring systems for bridges. The focus of this paper is on the illustration of the Monitoring Regional (MoRe) guidelines and of their implementation on nine pilot monitoring systems designed and deployed within the project. The (MoRe) guidelines tackle the entire monitoring process from the analyses of the monitoring goals and the preliminary investigations needed to the identification of the phenomena and relevant indicators to monitor, up to the selection of monitoring devices and the presentation of results. A short illustration of the permanent monitoring systems installed on nine exemplary bridges in the Lombardia region concludes the paper.