Objective: To compare oncological and functional results of open and laparoscopic radical prostatectomy in patients with prostate cancer. Materials And Methods: A retrospective cohort analytical study was carried out, where a total of 70 patients with a clinical diagnosis of localized prostate cancer were evaluated, during the period June 2010 to June 2015. The patients were grouped according to the technique used: Open surgery (n = 40) and laparoscopic surgery (n = 30). Preoperative variables were analyzed (age, prostate-specific antigen, biopsy histology, functional status and comorbidities), perioperative (surgical time, intraoperative bleeding, hospital stay and complications), postoperative: Oncological (stage, histological findings of the surgical specimen and TNM) and postoperative functional (urinary continence and potency or sexual performance). Results: No significant differences were found in oncological results; but if in intraoperative bleeding (1177 vs 440 cc; p <0.001), hospital stay (5.8 vs 4.6 days; p = 0.003), complications (35 vs 10%; p = 0.016) and continence (65 vs 93%; p = 0.018), in favor of the laparoscopic technique. When evaluating the surgical time, it was found that it was shorter with the open technique (242 vs 295 minutes; p <0.001). Conclusions: At 60 months of follow-up, there was no significant difference in oncological results or sexual potency between the two groups. With the laparoscopic technique, less intraoperative bleeding, fewer intraoperative and postoperative complications, shorter hospital stay and better recovery from urinary continence were found.