We report 2 cases of patients with a history of laser in situ keratomileusis (LASIK) surgery. Endothelial damage resulted from complicated phacoemulsification in 1 patient and from iris-fixated phakic intraocular lens implantation in the other patient. Descemet membrane endothelial keratoplasty (DMEK) was performed to correct the damaged endothelium. After uneventful surgery, both patients presented with liquid interface beneath the LASIK flap, which was evident on anterior segment optical coherence tomography (OCT). In both cases, the LASIK flap was lifted, the liquid removed, and the flap placed correctly. Significant improvement in the corneal appearance and the corrected distance visual acuity was seen. Anterior segment-OCT showed resolution of the flap interface.