Heat transport keeps vital impact in field of engineering like heat spacing, air conditioning, refrigeration, and in chemical processing, such as heating of base and final products, heat recovery, tempering of containers, autoclaves, and reactors. This manuscript reveals theoretical and an experimental finding related for heat transport of unsteady cross nanofluid and chemical process with inclined magnetic field over the wedge. Heat transport is scrutinized with the existence of nonuniform heat sink source and radiation. Furthermore, mass transfer is studied with higher order chemical process, thermophoresis, and Brownian motion. Mathematical system produces nonlinear partial differential equations (PDEs) of time-dependent velocity, energy, and concentration. Moreover, these PDEs changed into the system of nonlinear ordinary differential equations (ODEs). The obtained ODEs are passed out through shooting technique to convert the boundary value problem into initial value problem and further bvp4c took them for numerical solution. Bvp4c is MATLAB procedure, which is most convergent for numerical solution of ODEs based on RK-45 procedure. Many applicable parameters are inspected graphically and in tabular form. Numerical outcomes related to physical quantities are hashed out in tabular form. Chemical process boosts the heat and mass transport. Higher radiation responses higher temperature and inclined magnetic strength reduces the velocity of cross nanofluid.