Title
Identification of the FtsK sequence-recognition domain
Date Issued
01 November 2006
Access level
metadata only access
Resource Type
journal article
Author(s)
University of California
Abstract
FtsK is a prokaryotic multidomain DNA translocase that coordinates chromosome segregation and cell division. FtsK is membrane anchored at the division septum and, guided by highly skewed DNA sequences, translocates the chromosome to bring the terminus of replication to the septum. Here, we use in vitro single-molecule and ensemble methods to unveil a mechanism of action in which the translocation and sequence-recognition activities are performed by different domains in FtsK. © 2006 Nature Publishing Group.
Start page
1023
End page
1025
Volume
13
Issue
11
Language
English
OCDE Knowledge area
Bioquímica, Biología molecular
Biología celular, Microbiología
DOI
Scopus EID
2-s2.0-33750580849
PubMed ID
Source
Nature Structural and Molecular Biology
ISSN of the container
15459985
Sponsor(s)
We dedicate this work to our friend and colleague Nick Cozzarelli, who passed away during preparation of this paper. We thank J. Moffitt, J. Gore, P. Pease and N. Crisona for critiques. US National Institutes of Health Grant GM31655 (J.L.P. and N.R.C.) and the Human Frontiers Science Organization (M.N.) supported this work.
Sources of information:
Directorio de Producción Científica
Scopus