Objective: To evaluate the health status of patients with amputations due to diabetic foot in two hospitals in Peru in 2017. Materials and methods: Cross-sectional descriptive study. Participants consisted of diabetic patients with amputation of at least one lower limb attended in an outpatient clinic, hospitalisation or emergency room at the Hospital Regional Lambayeque and Hospital Regional Docente Las Mercedes. The instruments used were the following: the 36-Item Short-Form Survey (36-SF) Quality of Life Scale, the Morisky-Green-Levine Scale, the Beck Depression Inventory and the Functional Independence Measure (FIM) to measure quality of life, treatment adherence, level of depression, and functional independence, respectively. Results: A total of 96 patients were surveyed, of whom 56 were male and 40 were female. The mean age was 58.25 ± 10.9 years and the median was 56.5 years. The median diagnosis length of diabetes mellitus was 13 years and the median amputation time was 21 months. A total of 59.38% had supracondylar amputation. The most commonly used mobility device was wheelchair in 82 patients (85.42%) and the most common comorbidity was arterial hypertension in 60 (62.5%). Quality of life was satisfactory in 66 patients (68.75%) and the most affected dimension was physical function (mean: 41.72); 57 patients (59.38%) were functionally independent, 72 (75%) had depressive symptoms, and 47.3% adhered to pharmacological treatment. Conclusions: Quality of life was satisfactory in most of the respondents and most had depression. Half of the patients were functionally independent and adhered to treatment.