This trial was carried out to evaluate the effects of replacing soybean meal with hydrolyzed protein of the cellular content of yeast (HPCCY), isolated protein of soy (IPS), hydrolyzed protein of intestinal mucosa membrane of swine (HPIMS) and dried whole milk on intestinal mucosa membrane morphology and pancreas development of weaned pigs at 7 and 14 days post weaning. Fourty-four piglets (averaging 5.5 ± 0.6 kg) were fed the following isonutritive diets: SM - yellow corn-soybean meal based diet; DWM - SM plus dried whole milk; DWM+HPIMS - DWM plus HPIMS; DWM+IPS - DWM plus IPS; DWM+HPCCY - DWM plus HPCCY. The treatments did not influence the pig intestinal structure, showing that none of the protein sources minimized the harmful effects of feeding change on the intestinal epithelium. DWM+HPIMS and DWM+IPS provided the greatest pancreatic weight at 7 days post weaning. It was concluded that all studied protein sources were adequate to formulate diets for weaned piglets.