Cognitive processes such as negative thoughts are important modulators of the pain experience. The Inventory of Negative Thoughts in Response to Pain (INTRP) is a tool that allows evaluating negative automatic thoughts associated with the painful experience. The present work focuses on the validation of the INTRP in the Argentine population. Several previous models were tested, reaching the best fit of the five-factor model: 1) negative selfverbalizations, 2) negative thoughts of social support, 3) thoughts of disability, 5) thoughts of lack of control and 5) thoughts of self-blame. This model has the same factor structure as that found in the Spanish version, which has a higher level of specificity in detecting cognitions associated with pain. It can be concluded that the INTRP is a reliable tool for use in the clinical setting that allows to focus the psychological therapy of Argentines with headaches.