Title
Lack of association between chronic exposure to biomass fuel smoke and markers of right ventricular pressure overload at high altitude
Date Issued
01 November 2014
Access level
open access
Resource Type
journal article
Author(s)
Caravedo M.
Painschab M.
Davila-Roman V.
De Ferrari A.
Pollard S.
Checkley W.
Escuela de Salud PĂºblica Bloomberg
CRĂ“NICAS, Centro de Excelencia en Enfermedades CrĂ³nicas Universidad McMaster
Abstract
Background: Chronic exposure to biomass fuel smoke has been implicated in the development of pulmonary hypertension and right ventricular pressure/volume overload through activation of inflammation, increase in vascular resistance, and endothelial dysfunction. We sought to compare N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and echocardiography-derived pulmonary artery systolic pressure (PASP) levels in a high-altitude population-based study in Peru with and without chronic exposure to biomass fuel smoke.
Start page
731
End page
738
Volume
168
Issue
5
Language
English
OCDE Knowledge area
Salud pĂºblica, Salud ambiental
Scopus EID
2-s2.0-84908374501
PubMed ID
Source
American Heart Journal
ISSN of the container
00028703
Sponsor(s)
The study population was comprised of adults (aged ≥35 years) living in Puno, Peru (population ~150, 000), and surrounding rural communities at 3, 825 m above sea level. City-dwellers work chiefly in commerce and education and cook predominantly with clean fuels including liquid-propane gas, kerosene, and electricity. Rural-dwellers live as subsistence farmers and cook indoors almost exclusively with traditional, open-fire stoves, and use combinations of wood, animal dung, and crop residue as fuel. All participants provided verbal informed consent after our research team read the entire informed consent document to them and any questions were answered. Informed consents were verbal because of high illiteracy rates. The study protocol was approved by the Johns Hopkins University in Baltimore, USA, and AB PRISMA and Universidad Peruana Cayetano Heredia in Lima, Peru. This work was supported by the Center for Global Health of Johns Hopkins University and by the National Heart, Lung and Blood Institute, United States National Institutes of Health. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the paper and its final contents.
Sources of information:
Directorio de ProducciĂ³n CientĂfica
Scopus