Title
Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever
Date Issued
27 July 2002
Access level
metadata only access
Resource Type
journal article
Author(s)
Kochel T.J.
Watts D.M.
Halstead S.B.
Hayes C.G.
Espinoza A.
Caceda R.
Bautista C.T.
Montoya Y.
Douglas S.
Russell K.L.
Naval Medical Research Centre
Publisher(s)
Elsevier B.V.
Abstract
In Iquitos, Peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by American genotype dengue-2 (American dengue-2) virus. We assayed serum samples collected in Iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two American dengue-2 viruses, and two Asian dengue-2 viruses. Sera positive for the dengue-1 antibody neutralised dengue-1 viruses and American dengue-2 viruses much more effectively than Asian dengue-2 viruses. Neutralisation of American dengue-2 virus by sera positive for dengue-1 antibodies may account for the absence of dengue haemorrhagic fever in individuals infected with dengue-1 in 1990-91 followed by American dengue-2 virus in 1995 in Iquitos, Peru.
Start page
310
End page
312
Volume
360
Issue
9329
Language
English
OCDE Knowledge area
Medicina tropical
Epidemiología
Scopus EID
2-s2.0-0037183318
PubMed ID
Source
Lancet
ISSN of the container
01406736
Sponsor(s)
We thank Karla Block and Rosa Burga for assistance during sample collection; Carlos Calampa, who authorised collection of samples from the Iquitos community on behalf of the Peruvian Ministry of Health; and Guillermo Comach of the Dengue Regional Laboratory, Maracay, Venezuela, for the Asian dengue-2 isolate OBS 8041. This research was supported by the US Naval Medical Research and Development Command NMMC, Bethesda, MD, Work Unit No 62787A8701447.
Sources of information:
Directorio de Producción Científica
Scopus