OBJECTIVE: To determine whether erradication of Helicobacter pylori (HP) infection from gastric mucosae is associated with changes in symptoms severity and satisfaction degree in patients with non-ulcer dyspepsia (NUD). METHODS: Prospective cohort study in patients with NUD and HP infection that were evaluated for six months following treatment, made up of 70 HP Negative patients in whom HP infection was erradicated, and 28 HP Positive patients in whom infection was not eradicated following treatment. Dyspeptic symptoms were assessed using SODA scale. RESULTS: There was significant differences on decrease of pain (RR= 0.6, IC 90%: 0.47 -0.78) and non-pain symptoms intensity (RR= 0.5, IC 90%: 0.39 - 0.67), as well as on increase on degree of satisfaction (RR= 3.28, IC 90%: 2.86 - 3.75) among HP Negative patients group with regards to HP Positive patients at sixth month. CONCLUSIONS: In patients with nonulcer dyspepsia, erradication of HP infection is associated with decrease in symptoms intensity and increase on degree of satisfaction six month after treatment.