Background: To evaluate the bracket-wire friction force after clinical use. Materials and Methods: A systematic search of several electronic databases (PubMed, Embase, Web of Science, Scopus, The Cochrane Library, Lilacs and Google Scholar) without limitations regarding publication year or language, was performed. In-vitro studies analyzing the changes in friction force of orthodontic brackets before/after their clinical use were considered. Risk of Bias was assessed with Downs and Black checklist. All methodological features that could interfere in the results were specifically described. Results: Seven studies satisfied the inclusion criteria and were included in the review. All 7 studies reported at least two groups (before and after clinical use). Friction force increased after intraoral aging in most of the studies. However, there is lack of good quality evidence in this research area. Conclusions: Brackets present increased surface roughness after clinical use, and consequently increased coefficient of friction (COF) and Friction Force. Further studies are necessary to obtain more reliable results.