Title
In vitro activity of lachesis muta and bothrops atrox venoms on the viability and embrionary development of ascaris suum eggs
Other title
[Actividad in vitro de los venenos de lachesis mutav bothrops afroxsobre la viabilidad y desarrollo embrionario de los huevos de ascaris suum]
Date Issued
01 January 1999
Access level
open access
Resource Type
journal article
Publisher(s)
Universidad Nacional Mayor de San Marcos, Fac. Of Biological Sci.
Abstract
Snake venoms are polienzymatic concentrated whose biological activity on some bacteria and protozoa has been proven. To study the in vitro activity of Lachesis muta and Bothrops atrox venoms on the viability and the development of Ascaris suum eggs is the main objective of this work. The venoms were employed in non embryonated and in vitro embryonated eggs of Ascaris suum at different concentrations (2, 4, 8,16 mg/mL). The activity of the venoms in the eggs and other substances like 5,25% sodium hypochlorite, Albendazol (commercial solution) and sodium chloride was compared. Both venoms, at 2, 4, 8, 16 mg/mL concentrations, inhibited segmentation of these eggs until the sixth day of incubation, when they began an apparently normal embryonation process that ended in the formation of the infective stage. The most effective inhibitory concentration was 16mg/mL of B. atrox venom. The sodium hypochlorite destroyed 100% of eggs, while Albendazol produced abnormal segmentation process on them and their degeneration. We conclude that L muta and B. atrox venoms have an inhibitory activity at the begining of segmentation in Ascaris suum eggs and they do not cause any effect on embryonated ones.
Start page
85
End page
93
Volume
6
Issue
1
Language
Spanish
OCDE Knowledge area
Toxicología
Scopus EID
2-s2.0-84986328172
Source
Revista Peruana de Biologia
ISSN of the container
15610837
Sources of information: Directorio de Producción Científica Scopus