Title
Comparison of three ELISAs for the routine diagnosis of human T-lymphotropic virus infection in a high-prevalence setting in Peru
Date Issued
01 April 2009
Access level
metadata only access
Resource Type
journal article
Author(s)
Verdonck K.
Maldonado F.
Agapito D.
Van Dooren S.
Vandamme A.
Vanham G.
Publisher(s)
Oxford University Press
Abstract
To compare three human T-lymphotropic virus (HTLV) ELISAs in a high-prevalence setting, we recruited 300 adults: 125 relatives of HTLV-infected subjects and 175 patients with possible diagnoses of HTLV-associated diseases. Sera were tested with Platelia, Murex, and Ortho ELISA. Samples with positive or discordant ELISA underwent confirmatory Inno-Lia testing. Inno-Lia gave 85/300 HTLV-1-positive and 1/300 HTLV-2-positive results. The positive predictive value was 98% for Platelia, and 100% for Murex and Ortho. Six samples had discordant ELISA; Murex gave one false-negative result, Ortho two and Platelia one. In high-prevalence settings, it is recommended to test samples with two ELISAs before considering them HTLV-seronegative. © 2008 Royal Society of Tropical Medicine and Hygiene.
Start page
420
End page
422
Volume
103
Issue
4
Language
English
OCDE Knowledge area
Tecnología para la identificación y funcionamiento del ADN, proteínas y enzimas y como influencian la enfermedad)
Dermatología, Enfermedades venéreas
Subjects
Scopus EID
2-s2.0-61449267420
PubMed ID
Source
Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN of the container
00359203
Sources of information:
Directorio de Producción Científica
Scopus