AIM: Our experience with the laparoscopic treatment of pancreatic insulinomas is reported. PATIENTS AND METHODS: Four patients with clinical and radiological diagnosis of insulinoma were treated between January 2000 and September 2005. RESULTS: All the patients were laparoscopically approached to attempt the tumor enucleation. In three cases complete enucleation was possible; the remaining case was converted to perform the resection of the middle portion of the pancreas. One patient developed a pancreatic fistula that closed spontaneously. In all cases histological evaluation of the tumor showed benign islet cell tumor. Blood glucose levels returned to normality. CONCLUSION: Laparoscopic enucleation of pancreatic insulinoma is a feasible and safe technique.