Title
Extending finite mixtures of t linear mixed-effects models with concomitant covariates
Date Issued
01 August 2020
Access level
metadata only access
Resource Type
journal article
Author(s)
Pontificia Universidad Católica de Chile
Publisher(s)
Elsevier B.V.
Abstract
The issue of model-based clustering of longitudinal data has attracted increasing attention in past two decades. Finite mixtures of Student's-t linear mixed-effects (FM-tLME) models have been considered for implementing this task especially when data contain extreme observations. This paper presents an extended finite mixtures of Student's-t linear mixed-effects (EFM-tLME) model, where the categorical component labels are assumed to be influenced by the observed covariates. As compared with the naive methods assuming the mixing proportions to be fixed but unknown, the proposed EFM-tLME model exploits a logistic function to link the relationship between the prior classification probabilities and the covariates of interest. To carry out maximum likelihood estimation, an alternating expectation conditional maximization (AECM) algorithm is developed under several model reduction schemes. The technique for extracting the information-based standard errors of parameter estimates is also investigated. The proposed method is illustrated using simulation experiments and real data from an AIDS clinical study.
Volume
148
Language
English
OCDE Knowledge area
Ingeniería médica
Estadísticas, Probabilidad
Subjects
Scopus EID
2-s2.0-85082968322
Source
Computational Statistics and Data Analysis
ISSN of the container
01679473
Sponsor(s)
The authors gratefully acknowledge the Editors, the Associate Editor and two anonymous referees for their comments and suggestions that greatly improved the quality of this paper. T.I. Lin and W.L. Wang would like to acknowledge the support of the Ministry of Science and Technology of Taiwan under Grant Nos. MOST 107-2118-M-005-002-MY2 and MOST 107-2628-M-035-001-MY3 . L.M. Castro acknowledges support from Grant FONDECYT, Chile 1170258 and Millennium Science Initiative of the Ministry of Economy, Development and Tourism, Chile , Grant “Millennium Nucleus Center for the Discovery of Structures in Complex Data” from the Chilean government.
Sources of information:
Directorio de Producción Científica
Scopus