Tuberculosis is a contagious infectious disease, caused by Mycobacterium Tuberculosis, transmitted through its release into the air when a sick person coughs, sneezes or talks, so it can be inhaled by another person and infect it, it is necessary for patients to adopt family, work and social distancing to avoid infections, causing a risk of developing different levels of depression, which is detrimental due to its negative influence on decision-making. The frequency of depression in society is high, as is the predisposition of patients diagnosed with Tuberculosis due to the sudden change in their lifestyle, which is why it was proposed to determine the level of depression in tuberculosis patients at health centers from Los Olivos district, this study will also allow to know the most frequent physical and psychological reactions, in addition to the most predominant sex. To obtain the information, the corresponding permits were obtained and the Patient Health Questionnaire 9 (PHQ-9), an international and nationally validated standardized instrument, was applied; the data was processed in the statistical software SPSS 24.0, and the graphics were subsequently extracted; where the following obtained results were reflected: 100% of the participants had some level of depression, the most prevalent being the level of moderate depression with 35.56%, being more present in the female population with 21.11%, it was also shown that 48.9% of patients almost always have little interest or pleasure in doing things.