Title
Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases
Date Issued
01 September 2018
Access level
metadata only access
Resource Type
journal article
Author(s)
Ashraf J.M.
Ansari M.A.
Fatma S.
Abdullah S.M.S.
Iqbal J.
Madkhali A.
Hamali A.H.
Ahmad S.
Jerah A.
Echeverria V.
Ashraf G.M.
Pontificia Universidad Javeriana
Publisher(s)
Humana Press Inc.
Abstract
Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson’s diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications.
Start page
7438
End page
7452
Volume
55
Issue
9
Language
English
OCDE Knowledge area
Neurología clínica
Subjects
Scopus EID
2-s2.0-85041513029
PubMed ID
Source
Molecular Neurobiology
ISSN of the container
08937648
Sponsor(s)
The authors thank Jazan University, Saudi Arabia, and Institute of Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, for providing instruments, facilities, and other items used in this study. Jalaluddin M. Ashraf and Mohammad Azam Ansari are equally contributing authors
Sources of information:
Directorio de Producción Científica
Scopus