In the context of the arrival of vaccines against COVID-19 in Peru, it is important to know which sectors are the most willing to be vaccinated. The objective of this study was to determine the socio-labor factors associated with the possibility of vaccination against COVID-19 if required by work. Analytical cross-sectional study, which had as its main question whether they would be vaccinated if it was a job requirement, this was compared according to work category, sex and age group; descriptive and analytical statistics were obtained. Of the 6628 workers surveyed, 34% and 35% would get vaccinated if required to do so by their job, based on whether they had not yet been sick or had already been sick, respectively. In the multivariate analysis, there was a higher frequency of agreement to be vaccinated among those in the mining sector (aPR: 1.33; 95%CI: 1.05-1.69; p-value=0.019), those doing domestic work (aPR: 1.14; 95%CI: 1.01-1.29; p-value=0.036) and men (aPR: 1.07; 95%CI. 1.01-1.14; p-value=0.029); in contrast, those in the younger age range 40-49 years (aPR: 0.82; 95%CI: 0.71-0.95; p-value=0.010) were less likely to be vaccinated than those in the younger age range (aPR: 0.82; 95%CI: 0.71-0.95; p-value=0.010). There was a low perception of the possibility of getting vaccinated if asked to do so at work, the main factors associated with the possibility of getting vaccinated being not having been previously infected with COVID-19, belonging to the mining sector, performing domestic work and being male.